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This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene.
Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. Gene Ontology GO annotations related to this gene include calcium ion binding and actin binding. An important paralog of this gene is DMD. Genes Participants. Jump to section. Antibodies Assays Proteins Inhib. The protein encoded by this gene is located at the neuromuscular synapse and myotendin See more May play a role in anchoring the cytoskeleton to the plasma membrane.